The Melcom building at Achimota in Accra has collapsed.
Rescue efforts are underway at the site.
A combined team of the police, Fire Service, National Disaster Management Organisation (NADMO) personnel and the Ambulance Service, are working hard to rescue an undisclosed number of people trapped in the building.
Unofficial reports say those trapped, are mainly staff of Melcom who had reported for work and were making preparations inside, to open the shop to the public.
Six people have so far been rescued from the rubble and rushed to the hospital.
Three are said to be dead. The figure is yet to be confirmed.
The six storey building, which was a-one-stop shop, collapsed at about 8.45 a.m Wednesday, about an hour and a half away from the start of normal business.
A large number of onlookers and relations of staff, who have thronged the site, are hampering rescue efforts.
Vice-President Paa Kwesi Amissah-Arthur and AMA boss, Mr Okoe Vanderpuye, have since rushed to the scene to help with the rescue operation.
President John Mahama, on hearing of the mishap, is also reported to have cut short his campaign to return to Accra.
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